The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

Blog Article

BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions vibrating table for chocolate between environmental and genetic factors.A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213.This study evaluated the association between preeclampsia and rs11646213.METHODS: A total of 454 cases and 460 controls were recruited to participate in this study.The single nucleotide polymorphism (SNP) rs11646213 was genotyped by polymerase chain reaction (PCR) and direct sequencing.

RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76).

Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03) and the early-onset preeclampsia subgroup (P = 0.

004, turbo air m3f24-1-n OR = 1.57, 95% CI = 1.16-2.13).Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia.

CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.